O’Garra Lab

086: O’Garra Lab

Created by Philippa Stimpson, Christina Taubert, Damian Carragher, Simon Blankley and Lucia Moreira- Teixeira.

We use diverse tools to study the molecular mechanisms underlying the induction and function of the regulatory cytokine Interleukin-10 (IL-10) in macrophages and T cells, versus the production of pro-inflammatory cytokines which may be protective but if uncontrolled will cause pathology. We also study the consequences of IL-10 action in mouse models of infectious diseases, with a strong emphasis on tuberculosis (TB) caused by the pathogen Mycobacterium tuberculosis (Mtb).

Using a systems biology approach we identified a robust blood transcriptional interferon-inducible signature in human TB and we are addressing the immune mechanisms of interferon related genes inducing protection or pathogenesis important for disease control in TB and other bacterial infections. Type I IFN identified in this transcriptional signature can induce the suppressive cytokine IL-10 and inhibit the protective cytokine IL-1 and IL-12 contributing to chronic infection.

The canvas background is an impression of a microarray heat map. The embroidery depicts a Mtb infected macrophage interacting with a T cell.

086-O’Garra Lab