Spinazzola lab – Mitochondrial biogenesis and disease group

052: Spinazzola lab – Mitochondrial biogenesis and disease group

Created by Alice Mitchell and Romina Durigon

Mitochondrial biogenesis is a fundamental area of eukaryotic cell biology, as the process requires the target, import and assembly of over 1,500 nuclear encoded proteins, to create double-membrane bound organelles. In addition mitochondria contain their own DNA, mtDNA, which in humans encodes 13 proteins, essential for ATP production via oxidative phosphorylation.

Our challenge is to understand how mitochondrial proteins cause mitochondrial diseases and the cellular signals and pathways that impact on the mitochondrial activity and function.

Alice and Romina like drawing and poetry, respectively. So Alice created and painted a pattern on the canvas of abstract curved lines, symbolising the different membranes of the mitochondria. The blending of colours hints at the fluidity and links between the various processes of the mitochondria.

Romina chose and wrote down the poem on the canvas. “Hold fast to dreams, for if dreams die, life is a broken-winged bird that cannot fly” is a verse taken from the poem “Dream” written by the US poet Langston Hughes. This poem is a strong statement that we should always remember, because dreaming helps human beings to achieve their desires and purposes.

Ilaria, Mara, Daniela and Aleck donated the little mouse’s head and gave us advice.

Romina Durigon
Alice Mitchell
Ilaria Dalla Rosa
Mara Mennuni
Daniela Mastronicola
Aleck William Jones
Antonella Spinazzola’s Lab, Division of Virology room 271

052-Spinazzola lab - Mitochondrial biogenesis and disease group